Toxic epidermal necrolysis: review of 15 cases
نویسندگان
چکیده
منابع مشابه
Review of Toxic Epidermal Necrolysis
Toxic epidermal necrolysis (TEN) is a rare but life threatening mucocutaneous reaction to drugs or their metabolites. It is characterised by widespread keratinocyte apoptosis and sloughing of the skin, erosions of the mucous membranes, painful blistering, and severe systemic disturbance. The pathophysiology of TEN is incompletely understood. Historically, it has been regarded as a drug-induced ...
متن کاملToxic epidermal necrolysis (TEN) : a clinical review
Background: Toxic epidermal necrolysis (TEN) is a severe life-threatening condition associatedwith a low incidence but high mortality rate ranging from 25-50%. TEN is characterized by itswidespread skin necrosis with frequent mucous membrane involvement. The pathophysiology ofTEN has yet to be fully understood, however the current understanding involves a limited scope.Objec...
متن کامل[Toxic epidermal necrolysis].
Toxic epidermal necrolysis is a potentially fatal dermatological disease. Large bullae covering extensive areas of the body cause continuous exfoliation of skin, which requires immediate medical attention. Intraoral manifestations may precede cutaneous lesions. Two cases with different treatment protocols are presented.
متن کاملToxic Epidermal Necrolysis
Figure 1. Generalized epidermolysis on anterior and posterior torso with crusty erosions on oral mucosa. DESCRIPTION A 33-year-old woman presents with diffuse rash 3 weeks after completing a course of Bactrim for a urinary tract infection. Erythematous maculopapular rash is evident on the trunk and extremities with painful, epidermal sloughing on the back leaving a moist, denuded dermis. Note t...
متن کاملIntrapartum Toxic Epidermal Necrolysis.
This syndrome was first described by Lyell (1956) in this country and by Lang and Walker (1956) in South Africa and has since been reported with increasing frequency. Beare (1962), in a comprehensive review, collected 35 cases from the published reports and described 10 further cases that he had observed personally. He suggests that it is unlikely that the syndrome could have been seen in the U...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2009
ISSN: 1364-8535
DOI: 10.1186/cc7654